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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Related Experiment Video

Updated: Dec 12, 2025

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery
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Anticancer DOX delivery system based on CNTs: Functionalization, targeting and novel technologies.

Alireza Yaghoubi1, Ali Ramazani2

  • 1Department of Chemistry, University of Zanjan, Zanjan 4537138791, Iran.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|August 9, 2020
PubMed
Summary

Carbon nanotubes (CNTs) offer a novel platform for drug delivery, effectively carrying anticancer drugs like doxorubicin (DOX) to cancer cells. This review explores CNT-based systems for enhanced DOX delivery and cancer treatment.

Keywords:
Anticancer doxorubicinCarbon nanotube -based drug delivery systems (CNT-based DDSs)Carbon nanotubesDrug delivery

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Biomedical Engineering

Background:

  • Carbon nanotubes (CNTs) possess unique properties like high aspect ratio and cellular uptake, making them suitable for drug delivery.
  • Their conjugated structure facilitates π-π stacking interactions with aromatic drug molecules.
  • Doxorubicin (DOX), an anthracycline anticancer drug, can be effectively adsorbed onto CNTs via π-π stacking.

Purpose of the Study:

  • To review the use of various CNT-based drug delivery systems (DDSs) for delivering doxorubicin (DOX).
  • To summarize current in vitro and in vivo research on DOX-loaded CNT-based DDSs.
  • To highlight emerging technologies for DOX delivery using CNT-based DDSs.

Main Methods:

  • Review of existing literature on CNT-based drug delivery systems.
  • Analysis of studies focusing on the functionalization and targeting of CNTs for drug delivery.
  • Examination of in vitro and in vivo experimental data for DOX-loaded CNT-based DDSs.

Main Results:

  • CNTs serve as effective nanocarriers for DOX, enabling targeted delivery to cancer cells.
  • Functionalization and targeting strategies enhance the efficacy of CNT-based DDSs.
  • Significant progress has been made in both in vitro and in vivo studies of DOX-loaded CNTs.

Conclusions:

  • CNT-based DDSs show great promise for improving cancer therapy by enhancing doxorubicin delivery.
  • Further research into functionalization and targeting techniques is crucial for optimizing these systems.
  • Emerging technologies are paving the way for more effective and targeted cancer treatments using nanocarriers.