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Gaucher's disease involving the maxillary sinuses
M R Schwartz1, J S Weycer, M H McGavran
1Department of Pathology, Baylor College of Medicine, Houston, TX 77030.
Archives of Otolaryngology--Head & Neck Surgery
|February 1, 1988
Summary
Gaucher's disease, a rare genetic disorder, can affect the paranasal sinuses, specifically the maxillary antra. This case report highlights the first documented instance of Gaucher's disease impacting these sinus cavities.
Area of Science:
- Genetics
- Rare Diseases
- Otolaryngology
Background:
- Gaucher's disease (GD) is a lysosomal storage disorder.
- It typically affects the spleen, bone marrow, and bones.
- Maxillary and mandibular bone involvement in GD is uncommon.
Observation:
- A 46-year-old male with known Gaucher's disease presented with sinusitis symptoms.
- Radiological imaging revealed opacification of the maxillary antra.
- Histopathological examination confirmed Gaucher's disease involvement.
Findings:
- This case represents the first documented instance of Gaucher's disease affecting the paranasal sinuses.
- Radiologic and histologic evidence confirmed maxillary antral involvement.
Implications:
- Highlights the potential for Gaucher's disease to manifest in the paranasal sinuses.
- Suggests considering Gaucher's disease in the differential diagnosis of sinusitis with bone involvement.
- Emphasizes the importance of comprehensive evaluation in patients with Gaucher's disease.