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Updated: Dec 12, 2025

Application of DNA Fingerprinting using the D1S80 Locus in Lab Classes

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Published on: July 17, 2021

Morphological control for molecular testing: a practical approach.

Irene Gullo^1,2, Ana Marques^1,2,3, Regina Pinto³

¹Department of Pathology, CHUSJ - Centro Hospitalar Universitário de São João EPE, Porto, Portugal.

Journal of Clinical Pathology

|August 9, 2020

Summary

This summary is machine-generated.

Accurate tumor cellularity assessment by pathologists is crucial for reliable molecular diagnostics. Training in microscopic morphological control enhances the precision of this critical step in cancer analysis.

Keywords:

morphological and microscopic findings pathology, molecular quality control

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Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

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Published on: September 20, 2016

Area of Science:

Pathology
Molecular Diagnostics
Oncology

Background:

Molecular aberrations in tumors guide diagnosis, prognosis, and treatment.
Pathologists are integral to molecular diagnostics, ensuring accurate tissue selection and analysis.
Estimating tumor cellularity is vital for interpreting molecular findings.

Purpose of the Study:

To equip morpho-molecular pathologists with tools for mastering microscopic morphological control.
To provide a training image set for improving tumor cellularity assessment.
To enhance the reliability of pathological diagnosis in molecular testing.

Main Methods:

Commentary on practical tools for microscopic morphological control.
Inclusion of a training image set for solid tumors.
Focus on manual macrodissection and tumor cell enrichment.

Main Results:

Morphological control reliability can be improved through targeted training.
Standardized training addresses potential pitfalls in cellularity estimation.
Enhanced pathologist training leads to more accurate molecular diagnostic interpretations.

Conclusions:

Mastering microscopic morphological control is essential for pathologists in molecular diagnostics.
Improved assessment of tumor cellularity directly impacts the interpretation of molecular test results.
Continuous training is key to refining pathological assessment in oncology.