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Updated: Dec 12, 2025

Author Spotlight: Transmitochondrial Cybrid Generation Using Cancer Cell Lines
Published on: March 17, 2023
The Significance of Mitochondrial Dysfunction in Cancer
Yongde Luo1,2, Jianjia Ma2, Weiqin Lu2
1School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou 325000, China.
Abstract:
As an essential organelle in nucleated eukaryotic cells, mitochondria play a central role in energy metabolism, maintenance of redox balance, and regulation of apoptosis. Mitochondrial dysfunction, either due to the TCA cycle enzyme defects, mitochondrial DNA genetic mutations, defective mitochondrial electron transport chain, oxidative stress, or aberrant oncogene and tumor suppressor signaling, has been observed in a wide spectrum of human cancers. In this review, we summarize mitochondrial dysfunction induced by these alterations that promote human cancers.
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