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Emerging Roles and Therapeutic Interventions of Aerobic Glycolysis in Glioma
Wei Han1, Jia Shi1, Jiachao Cao1
1Department of Neurosurgery, The Third Affiliated Hospital of Soochow University, Changzhou, People's Republic of China.
Abstract:
Glioma is the most common type of intracranial malignant tumor, with a great recurrence rate due to its infiltrative growth, treatment resistance, intra- and intertumoral genetic heterogeneity. Recently, accumulating studies have illustrated that activated aerobic glycolysis participated in various cellular and clinical activities of glioma, thus influencing the efficacy of radiotherapy and chemotherapy. However, the glycolytic process is too complicated and ambiguous to serve as a novel therapy for glioma. In this review, we generalized the implication of key enzymes, glucose transporters (GLUTs), signalings and transcription factors in the glycolytic process of glioma. In addition, we summarized therapeutic interventions via the above aspects and discussed promising clinical applications for glioma.
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