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Epithelial morphogenesis in the perinatal mouse uterus.

Zer Vue1,2, Richard R Behringer1,2

  • 1Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, USA.

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The perinatal mouse uterus develops distinct dorsal-ventral and left-right patterns in its luminal epithelium shortly after birth. These early morphological changes are crucial for uterine gland formation and female fertility.

Keywords:
adenogenesisfemale reproductive tractpostnatal development

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Area of Science:

  • Developmental biology
  • Reproductive biology
  • Mammalian embryology

Background:

  • The uterus is vital for mammalian reproduction, housing endometrial glands essential for fertility.
  • Uterine gland formation (adenogenesis) begins postnatally in mice.
  • Previous studies utilized 3D fluorescent microscopy for imaging adult uteri and embryos.

Purpose of the Study:

  • To investigate the morphological development of the perinatal mouse uterine epithelium.
  • To characterize early epithelial changes preceding uterine gland formation.

Main Methods:

  • Utilized light sheet fluorescent microscopy for high-resolution 3D imaging.
  • Examined uterine morphology at specific postnatal time points (P3-P6).
  • Applied a 3D-staging system for developmental analysis.

Main Results:

  • Dorsoventral patterning of the uterine epithelium observed by postnatal day 3 (P3).
  • Uterine gland buds appeared by postnatal day 4 (P4).
  • Novel structures like a ventral ridge and uterine segments were identified.

Conclusions:

  • The perinatal mouse uterine luminal epithelium establishes dorsal-ventral patterning by P3-P4.
  • Left-right segmentation, defined by epithelial folds, emerges between P5-P6.
  • These early epithelial developments are foundational for uterine function and fertility.