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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
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Updated: Sep 11, 2025

The Soft Agar Colony Formation Assay
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WNT7A.

Naomi M Calhoun1, Richard R Behringer1

  • 1Department of Genetics, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

Differentiation; Research in Biological Diversity
|August 15, 2025
PubMed
Summary
This summary is machine-generated.

WNT7A is crucial for development, regulating signaling pathways and tissue formation. Mutations cause severe limb, reproductive, and nervous system defects, highlighting its essential role in human health and disease.

Keywords:
LimbNervous systemUterus

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Area of Science:

  • Developmental Biology
  • Molecular Signaling
  • Genetics

Background:

  • WNT7A is a signaling protein involved in numerous biological processes.
  • It activates canonical and non-canonical WNT pathways, influencing cellular behavior.
  • WNT7A expression is observed in critical developing tissues like the central nervous system and limb buds.

Purpose of the Study:

  • To summarize the regulatory roles of WNT7A in development.
  • To highlight the consequences of WNT7A dysfunction in various model organisms and humans.
  • To underscore the association between WNT7A alterations and cancer.

Main Methods:

  • Review of existing literature on WNT7A function.
  • Analysis of data from mouse and zebrafish models with Wnt7a mutations.
  • Examination of human genetic studies and cancer-related expression data.

Main Results:

  • Wnt7a mutations in mice lead to limb malformations, reproductive organ defects, infertility, and impaired cerebellar development.
  • Zebrafish wnt7aa mutants display neurogenesis and angiogenesis defects.
  • Human WNT7A mutations are linked to severe limb and pelvic bone abnormalities.
  • Altered WNT7A expression correlates with various cancers.

Conclusions:

  • WNT7A is essential for normal embryonic development, including limb, reproductive, and nervous system formation.
  • Dysregulation of WNT7A signaling has profound implications for developmental disorders and cancer.
  • Further research into WNT7A pathways may offer therapeutic targets for related diseases.