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Updated: Dec 12, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

Reducing the Risk for Postpartum Depression in Adolescent Mothers: A Randomized Controlled Trial.

Maureen G Phipps¹, Crystal F Ware, Robert L Stout

¹Departments of Obstetrics and Gynecology and Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, the Department of Epidemiology, Brown University School of Public Health, the Department of Obstetrics and Gynecology, Women & Infants Hospital of Rhode Island, and the Women & Infants Hospital of Rhode Island, Providence, Rhode Island; the University of Cape Town, Cape Town, South Africa, and the Pacific Institute for Research and Evaluation, Beltsville, Maryland.

Obstetrics and Gynecology

|August 10, 2020

Summary

This summary is machine-generated.

An interpersonal therapy intervention did not reduce postpartum depression in adolescents. The study found no significant difference in major depressive episodes between the intervention and control groups.

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Using Chronic Social Stress to Model Postpartum Depression in Lactating Rodents

Using Chronic Social Stress to Model Postpartum Depression in Lactating Rodents

Published on: June 10, 2013

Area of Science:

Perinatal mental health
Adolescent health
Psychosocial interventions

Background:

Postpartum depression (PPD) is a significant concern affecting maternal well-being.
Adolescents are particularly vulnerable to PPD due to unique psychosocial challenges.
Effective interventions are needed to mitigate PPD risk in this population.

Purpose of the Study:

To evaluate the efficacy of an interpersonal therapy (IPT)-based intervention in reducing the risk of postpartum depression among pregnant adolescents.
To assess the long-term impact of the intervention on major depressive episodes up to 12 months postpartum.

Main Methods:

A randomized controlled trial (RCT) involving 250 pregnant adolescents (age ≤18 years at conception).
Participants were randomized to an IPT-based intervention or a control group receiving standard pregnancy education.
Intervention included five prenatal and one postpartum booster session; outcomes assessed via structured diagnostic interviews.

Main Results:

The rate of major depressive episode by 12 months postpartum was 7.0% in the control group and 7.6% in the intervention group.
No statistically significant difference in the rate of major depressive episodes was observed between the groups (P=.88).
The observed rate of major depressive episodes was lower than anticipated in the control group.

Conclusions:

The IPT-based intervention did not demonstrate a significant benefit in reducing postpartum depression rates among adolescents.
Lower-than-predicted depression rates in the control group may be attributed to enhanced community resources.
Further research may be needed to explore effective interventions for adolescent PPD.