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Updated: Dec 12, 2025
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Preoperative soluble VCAM-1 contributes to predict late mortality after coronary artery surgery
Ramon Corbalan1, Mauricio Garcia1, Luis Garrido-Olivares2
1Division of Cardiovascular Diseases, Faculty of Medicine, Pontificia Unversidad Catolica de Chile, Santiago, Chile.
Insights
Preoperative soluble vascular cell adhesion molecule-1 (sVCAM-1) levels predict mortality risk in patients undergoing coronary artery bypass surgery. Elevated sVCAM-1, along with postoperative atrial fibrillation (POAF) and CHA2DS2-VASc score, are linked to increased death risk.
Area of Science:
- Cardiovascular Medicine
- Biomarkers
- Surgical Outcomes
Background:
- Soluble vascular cell adhesion molecule-1 (sVCAM-1) is linked to cardiovascular mortality and new-onset atrial fibrillation.
- Its role in predicting long-term outcomes after coronary artery bypass surgery (CABS) requires further investigation.
Purpose of the Study:
- To evaluate the predictive value of preoperative sVCAM-1 for all-cause and cardiovascular death in patients undergoing elective CABS.
- To compare the prognostic significance of sVCAM-1 with inflammatory markers, CHA2DS2-VASc score, and postoperative atrial fibrillation (POAF).
Main Methods:
- A cohort of 312 patients undergoing elective CABS were prospectively followed for a median of 6.7 years.
- Preoperative sVCAM-1 levels, inflammatory markers, CHA2DS2-VASc score, and POAF incidence were assessed.
- Univariable and multivariable Cox regression analyses were used to determine associations with mortality.
Main Results:
- During 2112 person-years, 41 deaths (10 cardiovascular) occurred.
- Elevated preoperative sVCAM-1, POAF, and CHA2DS2-VASc score were associated with all-cause mortality.
- Multivariate analysis identified preoperative sVCAM-1 and POAF as independent predictors of all-cause death, and sVCAM-1, POAF, and CHA2DS2-VASc score for cardiovascular mortality.
Conclusions:
- Increased preoperative sVCAM-1 levels are a significant independent predictor of long-term all-cause and cardiovascular mortality after CABS.
- sVCAM-1, in conjunction with POAF and CHA2DS2-VASc score, provides valuable prognostic information for patients undergoing CABS.
Background:
Soluble vascular cell adhesion molecule-1 has been associated with long-term cardiovascular mortality in patients with stable coronary artery disease and to the development of new atrial fibrillation in subjects with cardiovascular risk factors but no evidence of cardiac disease.
Hypothesis:
Preoperative soluble vascular cell adhesion molecule-1 predicts the risk of future all-cause death and cardiovascular death among patients submitted to elective coronary artery bypass surgery.
Methods:
From a cohort of 312 patients who underwent elective coronary artery bypass surgery prospectively followed for a median of 6.7 years, we evaluated the prognostic role of preoperative soluble vascular cell adhesion molecule-1, inflammatory markers, CHA2DS2-VASc score and development of postoperative atrial fibrillation (POAF). Univariable and multivariable Cox regression analyses were performed to establish an association of these parameters with long term all-cause death and cardiovascular death.
Results:
During 2112 person-years of follow-up, we observed 41 deaths, 10 were cardiovascular deaths. Independently increased levels of preoperative soluble vascular cell adhesion molecule-1, POAF, and CHA2DS2-VASc score were associated with all-cause mortality. After multivariate adjustment, elevated preoperative soluble vascular cell adhesion molecule-1 and POAF were the only independent predictors of all-cause death. Also, preoperative soluble vascular cell adhesion molecule-1, POAF, and CHA2DS2-VASc score resulted in being independent predictors of cardiovascular mortality.
Conclusions:
Increased circulating levels of preoperative soluble vascular cell adhesion molecule-1, together with POAF and CHA2DS2-VASc score, were significantly associated with future all-cause death and cardiovascular death among patients submitted to coronary artery bypass surgery.
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