Potential treatment methods targeting 2019-nCoV infection

Area of Science:

• * Virology: Classification of 2019-nCoV as a single-stranded RNA virus within the betacoronavirus family.
• * Molecular Biology: Identification of ACE2 receptors and Mpro as key targets for viral entry and replication.

Background:

• * The novel coronavirus (2019-nCoV) emerged as a significant global public health threat.
• * Clinical manifestations include fever, cough, myalgia, fatigue, and diarrhea.
• * Genetic sequencing reveals close relation to SARS-CoV and MERS-CoV.

Purpose of the Study:

• * To review current and potential treatment strategies for 2019-nCoV infection.
• * To consolidate information on chemical drugs, Traditional Chinese Medicine, convalescent plasma, and vaccines.
• * To provide an overview of drug targets, activity, clinical status, and adverse effects.

Main Methods:

• * Comprehensive literature review of real-time information on 2019-nCoV treatments.
• * Focused analysis of chemical drugs: lopinavir/ritonavir, chloroquine, hydroxychloroquine, arbidol, remdesivir, favipiravir.
• * Inclusion of Traditional Chinese Medicine, convalescent plasma therapy, biological reagents, and vaccine candidates.

Main Results:

• * Detailed description of chemical drugs, including their mechanisms of action, clinical efficacy, and safety profiles.
• * Evaluation of non-chemical therapeutic options such as Traditional Chinese Medicine and convalescent plasma.
• * Discussion of promising vaccine candidates under development.

Conclusions:

• * A wide range of therapeutic interventions are being investigated for 2019-nCoV.
• * Understanding drug targets, activity, and side effects is crucial for effective treatment.
• * Continued research into novel molecules, TCM, CPT, and vaccines is essential to combat the pandemic.