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Related Experiment Video

Updated: Dec 12, 2025

Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells
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Exosomes: Multifaceted Messengers in Atherosclerosis.

Hongyun Wang1,2, Yuling Xie1, Ane M Salvador3

  • 1Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, 333 Nan Chen Road, Shanghai, 200444, China.

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|August 11, 2020
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Summary

Exosomes play key roles in atherosclerosis (AS) development, diagnosis, and therapy. This review highlights exosome targets and intercellular communication in AS, offering insights for novel therapeutic strategies.

Keywords:
AtherosclerosisCross-talkEndothelial cellExosomeVSMC

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Area of Science:

  • Cardiovascular Research
  • Cell Biology
  • Biomedical Science

Background:

  • Atherosclerosis (AS) is a chronic inflammatory disease and a leading cause of coronary artery disease.
  • Current treatments for AS lack complete efficacy, necessitating novel therapeutic approaches.
  • Exosomes are increasingly recognized for their roles in AS pathogenesis and as potential diagnostic and therapeutic tools.

Purpose of the Study:

  • To review recent advances in understanding exosome targets and their function in intercellular communication in AS.
  • To provide insights into novel and effective therapeutic strategies for AS.
  • To elucidate the multifaceted role of exosomes in the diagnosis, development, and treatment of AS.

Main Methods:

  • Literature review of recent advances in exosome research related to atherosclerosis.
  • Analysis of exosome-mediated intercellular communication pathways in AS.
  • Synthesis of findings on exosome targets, diagnostic markers, and therapeutic applications in AS.

Main Results:

  • Exosomes mediate AS development through mechanisms involving TET2 repression, MALTA1-induced NETs, and miR-21-3p promoting VSMC proliferation.
  • Plasma exosomal-miR30e and miR-92a show potential as diagnostic markers for AS.
  • Adipose mesenchymal stem cell-derived exosomes demonstrate therapeutic potential by protecting endothelial cells.

Conclusions:

  • Exosomes are crucial in regulating vascular cell function and AS progression.
  • Exosomes hold significant promise as diagnostic biomarkers for AS.
  • Exosome-based therapies represent a novel and effective strategy for managing AS.