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Towards Neuro-CoViD-19.

Francesco Chiappelli1

  • 1UCLA Center for the Health Sciences, Los Angeles, California, USA.

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|August 11, 2020
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Summary
This summary is machine-generated.

Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2) may cause Neuro-CoViD-19 by binding to the angiotensin-converting enzyme-2 receptor (ACE2-R) in the brain. This interaction could disrupt ACE2

Keywords:
Angiotensin-converting enzyme-2 receptor (ACE2-R)Central Nervous System (CNS)Corona Virus Disease 2019 (CoViD-19)Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2)transmembrane protease serine-2 (TMPRSS2)

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Area of Science:

  • Neuroscience
  • Virology
  • Immunology

Background:

  • COVID-19, caused by SARS-CoV-2, involves S protein binding to ACE2-R.
  • ACE2 normally counteracts ACE's neurotoxic effects in the central nervous system (CNS).
  • SARS-CoV-2 can enter the CNS through circulation or cranial nerve I.

Discussion:

  • SARS-CoV-2 binding to ACE2-R may inactivate ACE2 in the CNS.
  • This inactivation could impair ACE2's protective role against ACE-mediated neurotoxicity.
  • This mechanism may contribute to neurological symptoms observed in COVID-19 patients.

Key Insights:

  • Proposes a neurobiological mechanism for Neuro-CoViD-19.
  • Highlights the role of SARS-CoV-2-ACE2 interaction in CNS pathology.
  • Suggests potential pathways for COVID-19-related neurological disorders.

Outlook:

  • Further research is needed to validate this proposed mechanism.
  • Understanding this pathway could inform therapeutic strategies for Neuro-CoViD-19.
  • Investigating ACE2's role in SARS-CoV-2 CNS infections is crucial.