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Related Experiment Video

Updated: Dec 12, 2025

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform

Published on: October 20, 2020

Nanoengineered Light-Activatable Polybubbles for On-Demand Therapeutic Delivery.

Shreedevi Arun Kumar¹, Jacob Good¹, David Hendrix¹

¹Biomedical Engineering College of Engineering Texas A&M University College Station TX 77843 USA.

Advanced Functional Materials

|August 11, 2020

Summary

This summary is machine-generated.

New polybubble technology offers thermostable vaccine delivery with delayed release, improving coverage in developing nations. Light-activatable nanoparticles enable on-demand therapeutic release for various treatments.

Keywords:

delayed burst diffusion drug depot light‐activatable polybubbles, nanomaterials stimuli responsive materials

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Last Updated: Dec 12, 2025

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform

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Published on: October 20, 2020

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Published on: January 24, 2025

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Published on: June 12, 2021

Area of Science:

Biomaterials Science
Nanotechnology
Vaccinology

Background:

Vaccine coverage is limited in developing countries due to poor vaccine stability and patient compliance.
Existing vaccine delivery systems often lack thermostability and controlled release mechanisms.

Purpose of the Study:

To develop an injectable, light-activatable polybubble platform for enhanced vaccine delivery.
To achieve thermostable vaccine storage and on-demand, delayed burst release of therapeutic cargo.

Main Methods:

Formation of injectable polybubbles encapsulating various cargo (small molecules, antigens).
Incorporation of near-infrared (NIR)-sensitive gold nanorods (AuNRs) for light-activatable properties.
In vitro, ex vivo, and in vivo studies to assess polybubble activation and cargo release.

Main Results:

Pol bubbles demonstrated delayed burst release of different cargo types.
NIR light successfully activated AuNR-loaded polybubbles for on-demand cargo release.
Successful in vitro, ex vivo, and in vivo activation of the polybubble system was confirmed.

Conclusions:

Light-activatable polybubble technology provides a promising solution for thermostable vaccine delivery.
The platform enables on-demand release of diverse therapeutics, including vaccines, drugs, and nucleic acids.
This technology has the potential to improve global vaccine coverage and therapeutic administration.