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Updated: Dec 12, 2025
Using Micro-computed Tomography for the Assessment of Tumor Development and Follow-up of Response to Treatment in a Mouse Model of Lung Cancer
Published on: May 20, 2016
Computed tomography texture analysis of response to second-line nivolumab in metastatic non-small cell lung cancer
Rahul Ladwa1,2, Kate E Roberts1,2, Connor O'Leary1,3
1Department of Medical Oncology, Princess Alexandra Hospital, Brisbane, QLD, Australia.
Objectives:
Assess computed tomography texture analysis of patients likely to benefit from nivolumab.
Materials & Methods:
Texture analysis was used to quantify heterogeneity within the largest tumor before immunotherapy. Histogram analysis was classified as hyperdense (positive skewness) or hypodense (negative skewness) and subclassified on median standard deviation value or entropy measurement.
Results:
47 patients were included. At a median follow-up of 18 months, statistical significant differences in progression-free survival were observed when stratified by positive skewness with low entropy, hazard ratio: 0.43 (0.19-0.95); p = 0.036, and positive skewness with low standard deviation, hazard ratio: 0.42 (0.18-0.96); p = 0.04.
Conclusion:
Patients who derive a clinical benefit to Nivolumab show a computed tomography texture of a hyperdense yet homogenous tumor.
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