Human coilin interacting nuclear ATPase protein in cancer: uncovering new insights into pathogenesis and therapy

A deeper understanding of tumor pathogenesis has revolutionized cancer treatment strategies. The discovery of human coilin interacting nuclear ATPase protein (hCINAP) and increasing experimental research over the past 15 years have provided us with new insights into the diagnoses, prognoses, and therapeutic approaches of cancer. In the current review, hCINAP's effect on tumor growth, cell viability, invasion, metastasis, and drug resistance is summarized. In addition, an overview is given of the underlying mechanisms involved, including regulation of signaling pathways, ribosome biogenesis, metabolism, as well as DNA damage repair. Finally, hCINAP-based therapeutic approaches are examined, with the goal of improving efficacy of cancer treatments. This review can, therefore, serve as a reference for further hCINAP-related research and clinical trials, and we advocate those approaches to be initiated without delay.