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Updated: Dec 12, 2025

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis

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Published on: February 9, 2021

Sevelamer Carbonate Crystal-Induced Colitis.

T Lai¹, A Frugoli², B Barrows³

¹Community Memorial Health System, Graduate Medical Education, Ventura, CA, USA.

Case Reports in Gastrointestinal Medicine

|August 11, 2020

Summary

Sevelamer carbonate, a phosphate binder, can cause colitis in end-stage renal disease patients. Discontinuing sevelamer improved symptoms, highlighting the need for awareness of this adverse effect.

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Murine Colitis Modeling using Dextran Sulfate Sodium DSS

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Published on: January 19, 2010

Area of Science:

Nephrology
Gastroenterology
Pathology

Background:

Hyperphosphatemia is a common complication in end-stage renal disease (ESRD).
Phosphate binders like sevelamer carbonate are crucial for managing secondary hyperparathyroidism in ESRD patients.
Dietary constraints alone are often insufficient to control phosphate levels.

Observation:

A 47-year-old male with diabetes and ESRD presented with abdominal pain and nausea.
CT scans revealed circumferential colonic lesions, raising concerns for ischemia or inflammatory bowel disease.
Colonoscopy showed nearly obstructing lesions, and pathology confirmed crystalline material consistent with sevelamer carbonate.

Findings:

Sevelamer carbonate was identified as the cause of colitis in this ESRD patient.
Discontinuation of sevelamer carbonate led to symptom resolution.
The patient transitioned to calcium carbonate with improved outcomes.

Implications:

Clinicians should consider sevelamer carbonate-induced colitis in ESRD patients with gastrointestinal complaints.
Increased awareness of this underreported adverse effect is crucial for appropriate patient management.
This case highlights the importance of considering medication side effects in complex patient cases.