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Postdischarge Health Care Costs and Readmission in Patients With Hyperkalemia-Related Hospitalizations
Keith A Betts1, J Michael Woolley2, Fan Mu1
1Analysis Group, Inc., Boston, Massachusetts, USA.
Insights
Hyperkalemia hospitalizations significantly increase healthcare costs and readmission rates within one year post-discharge. This study quantifies the substantial economic and readmission burdens associated with hyperkalemia.
Area of Science:
- Health Economics
- Clinical Outcomes Research
- Nephrology
Background:
- Limited data exists on the economic impact and readmission rates following hyperkalemia hospitalizations.
- Understanding these burdens is crucial for healthcare resource allocation and patient management.
Purpose of the Study:
- To evaluate the postdischarge economic costs and readmission rates associated with hyperkalemia hospitalizations.
- To compare healthcare resource utilization between patients with and without hyperkalemia.
Main Methods:
- A 1:1 matched cohort study using IBM MarketScan data (2010-2014).
- Adult patients hospitalized with hyperkalemia were matched with those without hyperkalemia based on key clinical factors.
- All-cause healthcare costs and resource utilization were compared for one year post-discharge.
Main Results:
- Hyperkalemia hospitalizations incurred $30,379 higher 1-year total costs and increased inpatient admissions, ED visits, and outpatient visits (P < 0.001).
- Readmission rates within 30, 60, and 90 days were significantly higher for hyperkalemia-related hospitalizations (P < 0.001).
- Longer length of stay per readmission and total inpatient days were observed in the hyperkalemia cohort (P < 0.001).
Conclusions:
- Hyperkalemia-related hospitalizations represent a significant economic burden.
- These hospitalizations are associated with substantially increased readmission rates and healthcare utilization post-discharge.
Introduction:
Limited evidence is available regarding the postdischarge economic and readmission burdens of hyperkalemia.
Methods:
Using the IBM MarketScan Commercial and Medicare-Supplemental Claims database (January 1, 2010-December 31, 2014), adult patients with a hospitalization with a hyperkalemia diagnosis (ICD-9-CM 276.7, hyperkalemia cohort) were 1:1 matched with patients with a hospitalization without evidence of hyperkalemia (nonhyperkalemia cohort) on age, chronic kidney disease stage, heart failure, dialysis, renin-angiotensin-aldosterone system inhibitor use, and major diagnostic categories of the hospitalization. All-cause health care costs and health care resource utilization measures were compared between cohorts during the 1-year postdischarge period. Postdischarge readmission and length of stay (LOS) were compared between hyperkalemia-related hospitalizations from the hyperkalemia cohort and matched hospitalizations unrelated to hyperkalemia from the nonhyperkalemia cohort.
Results:
Patients with hyperkalemia-related hospitalizations (n = 4426) incurred $30,379 (95% confidence interval, $25,423-$35,335) higher 1-year total all-cause costs ($68,861 vs. $38,482) and had higher rates of inpatient admissions (1.0 vs. 0.4), emergency department visits (2.0 vs. 1.2), and outpatient visits (49.6 vs. 39.1) than the nonhyperkalemia cohort during the 1-year postdischarge study period (all P < 0.001). Hyperkalemia-related hospitalizations (n = 5377) were associated with significantly higher readmission rates (within 30 days: 0.15 vs. 0.09; 60 days: 0.25 vs. 0.16; 90 days: 0.36 vs. 0.23; all P < 0.001), longer LOS per readmission (8.1 vs. 7.1 days), and longer total inpatient days (10.5 vs. 5.8 days) compared with hospitalizations unrelated to hyperkalemia (all P < 0.001). Similar trends were observed across comorbidity subgroups.
Conclusion:
Hyperkalemia-related hospitalizations were associated with significant economic and readmission burdens during the 1-year postdischarge period.
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