Related Experiment Video
Updated: Dec 12, 2025

08:13
Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
Published on: January 7, 2018
70.9K
Time-Restricted Feeding and Potential for Type 2 Diabetes Mellitus: A Narrative Review
The Journal of the American Osteopathic Association
|August 11, 2020
Summary
Time-restricted feeding (TRF), a popular intermittent fasting (IF) method, may aid weight loss and improve metabolic health. However, more research is needed to fully understand its effects, especially for type 2 diabetes patients.
Area of Science:
- Nutrition Science
- Metabolic Health
- Cardiovascular Health
Background:
- Intermittent fasting (IF) is a popular weight loss strategy.
- Time-restricted feeding (TRF) is a specific IF regimen with daily 16-hour fasts.
- TRF's effects on metabolic health are not fully understood.
Purpose of the Study:
- To review the potential benefits of TRF for weight loss and metabolic health.
- To analyze TRF's cardiovascular effects.
- To assess TRF's applicability for patients with type 2 diabetes mellitus.
Main Methods:
- Narrative literature review of studies on TRF.
- Analysis of manuscripts for potential benefits and limitations.
- Focus on TRF's impact on weight, insulin function, and cardiovascular markers.
Main Results:
- TRF may lead to mild weight loss and improved insulin function.
- TRF is associated with decreased blood pressure and fasting blood triglycerides.
- TRF combined with exercise may enhance fat loss.
Conclusions:
- TRF shows potential benefits for metabolic health and cardiovascular markers.
- Evidence for TRF's benefits, particularly for type 2 diabetes, is limited.
- Further research is necessary to validate TRF's effects and establish its clinical utility.
Related Concept Videos
Diabetes Mellitus: Type 2 and Gestational
4.1K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.1K
Diabetes Mellitus: Overview and Type I Subtype
4.7K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
4.7K
Carbohydrate Metabolism
13.3K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
13.3K
Diabetes: Management and Pharmacotherapy
766
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
766
Insulin: Dosing Regimen and Adverse Effects
542
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
542
Pathophysiology of Diabetes
2.9K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
2.9K

