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[Epidemiology and treatment of fungal keratitis]

N I Davletshina1,2, A N Samoylov1,2

  • 1Kazan State Medical University, Kazan, Russia.

Vestnik Oftalmologii
|August 12, 2020
PubMed

Insights

Fungal keratitis is increasing globally, with limited treatment options in many regions. This study reviews current epidemiology and available antifungal drugs to improve fungal keratitis management.

Area of Science:

  • Ophthalmology
  • Mycology
  • Infectious Diseases

Background:

  • Infectious keratitis is primarily caused by bacterial, viral, or fungal agents, with evolving structures.
  • A notable rise in fungal corneal lesions has been observed globally in recent decades.
  • Effective local etiological therapies for fungal keratitis are scarce, particularly in developing nations.

Purpose of the Study:

  • To address the growing challenge of fungal keratitis (ophthalmomycosis).
  • To review current global epidemiological data on fungal keratitis.
  • To analyze existing antifungal treatments and explore prospects for developing accessible and effective therapies.

Main Methods:

  • Literature review of research data on fungal keratitis epidemiology worldwide.
  • Analysis of currently available antifungal drugs for treating fungal keratitis.
  • Exploration of future therapeutic development strategies for fungal keratitis.

Main Results:

  • Fungal keratitis presents a significant global health challenge, exacerbated by limited treatment availability.
  • Treatment in some regions, like the Russian Federation, relies on off-label medications.
  • Inequitable access to diagnostic tools and approved therapies contributes to poor patient outcomes and potential vision loss.

Conclusions:

  • The study of fungal keratitis remains highly relevant due to increasing incidence and treatment disparities.
  • There is a critical need for improved diagnostic skills, accessible therapies, and increased "myco-caution" among healthcare professionals.
  • Developing affordable and effective antifungal treatments is essential to combat the detrimental effects of fungal keratitis.
Keywords:
PAC-CXLantifungal drugscrosslinkingepidemiologyfungal keratitiskeratomycosiskeratoplasty

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