Mutation-Simulator: fine-grained simulation of random mutations in any genome
M A Kühl1, B Stich1, D C Ries1
1Quantitative Genetics and Genomics of Plants, Heinrich Heine University, Düsseldorf 40225, Germany.
Summary:
Mutation-Simulator allows the introduction of various types of sequence alterations in reference sequences, with reasonable compute-time even for large eukaryotic genomes. Its intuitive system for fine-grained control over mutation rates along the sequence enables the mimicking of natural mutation patterns. Using standard file formats for input and output data, it can easily be integrated into any development and benchmarking workflow for high-throughput sequencing applications.
Availability And Implementation:
Mutation-Simulator is written in Python 3 and the source code, documentation, help and use cases are available on the Github page at https://github.com/mkpython3/Mutation-Simulator. It is free for use under the GPL 3 license.
Related Concept Videos
Mutations in Microorganisms
Gene Evolution - Fast or Slow?
In contrast, regions which code...
Mutation, Gene Flow, and Genetic Drift
Genetic Screens
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
Spontaneous and Induced Mutations
Viral Mutations


