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GIT/PIX Condensates Are Modular and Ideal for Distinct Compartmentalized Cell Signaling

Jinwei Zhu1, Qingqing Zhou2, Yitian Xia3

  • 1State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai 200240, China.

Molecular Cell
|August 12, 2020
PubMed
Summary

Cells use enzyme condensates for signaling. The GIT1/β-Pix complex forms phase-separated condensates, enabling targeted enzyme concentration at cellular sites for precise functions like migration and synapse formation.

Keywords:
GIT/PIX complexGTPase-activating proteinbiological condensatesfocal adhesionguanine nucleotide exchange factormembrane-less organellesphase separationsynapse formation

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