Related Experiment Video
Updated: Aug 14, 2026
07:55
Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer
Published on: January 17, 2025
Engineering CXCL10-enriched macrophage-derived extracellular vesicles for T cell recruitment and immune remodeling in
Shiyao Yin1, Ming Li1,2,3, Yanan Li1
1College of Pharmaceutical Sciences and Department of Otolaryngology, Children's Hospital, Suzhou Medical College, Soochow University Suzhou 215123 China ynli@suda.edu.cn.
Nanoscale Advances
|August 13, 2026
Abstract:
CXCL10-enriched macrophage-derived extracellular vesicles were engineered to reprogram the pancreatic tumor microenvironment. CXCL@MEVs enabled bioactive CXCL10 presentation, drove M2-to-M1 macrophage repolarization, recruited and activated CD8+ T cells, and suppressed PANC02 tumor growth with minimal systemic toxicity.
