Immune interactions between Drosophila and the pathogen Xenorhabdus

Deciphering host innate immune function and bacterial pathogenic tactics require a system that facilitates both facets of host-pathogen interactions. In recent years, a model that becomes established in dissecting mechanisms of host antibacterial immune response through probing with a potent bacterial pathogen involves the fruit fly Drosophila melanogaster and the insect pathogenic bacteria Xenorhabdus spp. The elegance of this system involves not only the genetic tractability of D. melanogaster, but also the association of Xenorhabdus with parasitic nematodes of insects that supervise the release of the bacteria as well as influence their pathogenic properties during the infection process. These dynamic aspects have enabled us to start decoding the specific features of the D. melanogaster host defense that participate in confronting the activity of Xenorhabdus molecular components, which are designed to evade the immune system. Here we outline recent information on the cellular, humoral and phenoloxidase reactions that are induced in D. melanogaster larvae and adults to oppose the Xenorhabdus attack, and the bacterial factors responsible for triggering these effects. This knowledge is critical not only for understanding how invertebrate immunity operates, but also for devising novel approaches to exploit the virulence ability of certain bacteria with the ultimate goal to counteract harmful insect pests or vectors of infectious disease.