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Corneal amyloidosis associated with keratoconus.
1Department of Ophthalmology, University of Florida College of Medicine, Gainesville 32610.
Ophthalmology
|January 1, 1988
Summary
Corneal amyloidosis, a rare condition, developed in a patient with keratoconus and hard contact lens wear. This case highlights the importance of considering secondary amyloidosis in such patients with unusual corneal opacities.
Area of Science:
- Ophthalmology
- Pathology
Background:
- Keratoconus is a progressive thinning of the cornea.
- Hard contact lens wear is common in keratoconus management.
- Corneal amyloidosis is a rare deposition of amyloid in the cornea.
Observation:
- A 50-year-old male with a history of hard contact lens wear for keratoconus developed nodular, gray-white central corneal opacities.
- The opacities involved the subepithelial zone and anterior stroma.
Findings:
- Histopathologic analysis of the corneal button revealed amyloid deposition as the cause of the opacities.
- The amyloid deposition pattern showed similarities to primary familial corneal amyloidosis.
- The authors suggest secondary amyloidosis is more likely in this case.
Implications:
- Corneal amyloidosis is a rare but possible complication in keratoconus patients, particularly those with long-term hard contact lens use.
- Consider corneal amyloidosis in keratoconus patients presenting with atypical central corneal opacification.
- This case expands the understanding of secondary amyloidosis etiologies.