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CD markers polymorphisms as prognostic biomarkers in hematological malignancies
Saeid Shahrabi1, Majid Ghanavat2, Masumeh Maleki Behzad3,4
1Department of Biochemistry and Hematology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan.
Oncology Reviews
|August 13, 2020
Summary
Single nucleotide polymorphisms (SNPs) in CD markers may offer prognostic insights for hematological malignancies like leukemia and lymphoma. Evaluating these genetic variations could improve diagnosis and treatment monitoring.
Area of Science:
- Hematology
- Genetics
- Oncology
Background:
- Clusters of differentiation (CD) markers are vital for cell immunophenotyping and classifying hematological malignancies.
- Single nucleotide polymorphisms (SNPs) are genetic variations that can alter CD marker expression and function.
- Existing research links CD marker polymorphisms to the risk of hematological cancers.
Purpose of the Study:
- To evaluate the prognostic significance of SNPs in CD markers within hematological malignancies.
- To explore the potential of CD marker SNPs as predictive biomarkers for leukemia and lymphoma.
Main Methods:
- A comprehensive literature search was conducted on PubMed from 2001 to 2019.
- Keywords included 'polymorphism', 'CD marker', 'leukemia', 'lymphoma', and 'prognosis'.
- English-language studies were analyzed to synthesize findings on CD marker SNPs and hematological malignancies.
Main Results:
- CD marker SNPs are associated with the risk of developing hematological malignancies.
- These genetic variations correlate with clinicopathological features, disease invasiveness, and treatment response.
- Polymorphisms in CD markers significantly impact disease outcomes.
Conclusions:
- SNPs in CD markers hold potential as prognostic biomarkers for hematological malignancies.
- Further research across diverse populations is needed to fully elucidate the role of CD marker SNPs.
- Understanding these genetic changes may facilitate earlier diagnosis and personalized treatment strategies.
