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Management of nail psoriasis with a single injection of abobotulinum toxin

Ayşenur Botsali1, Hakan Erbil2

  • 1Dermatology Department, Gulhane Training and Research Hospital, Health Sciences University, Ankara, Turkey.

Journal of Cosmetic Dermatology
|August 13, 2020
PubMed

Keywords:
abobotulinum toxinbotulinum toxindermoscopyonycholysisonychoscopypittingpsoriasispsoriatic nail

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Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin01:26

Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin

Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
The binding of dantrolene to the RYR1...
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