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Electroresponsive Silk-Based Biohybrid Composites for Electrochemically Controlled Growth Factor Delivery.

Adrián Magaz1,2, Mark D Ashton3, Rania M Hathout4

  • 1Department of Materials and Henry Royce Institute, The University of Manchester, Manchester M13 9PL, UK.

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Summary

Researchers developed electroresponsive biohybrid composites for controlled drug delivery. These materials precisely release therapeutics like nerve growth factor-beta (NGF-β) on demand, aiding tissue regeneration.

Keywords:
biohybridconductivitygrowth factornerve repairreduced graphene oxidesilkstimuli-responsive delivery

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Drug Delivery Systems

Background:

  • Stimuli-responsive materials offer on-demand drug delivery for tissue repair.
  • Controlled release of high-molecular-weight therapeutics remains a challenge.
  • Biohybrid composites are promising for regenerative medicine applications.

Purpose of the Study:

  • To develop electroresponsive biohybrid composites for controlled drug delivery.
  • To investigate the release kinetics of nerve growth factor-beta (NGF-β) from these composites.
  • To explore applications in neural tissue engineering and other electrically sensitive tissues.

Main Methods:

  • Fabrication of electroresponsive biohybrid composites using Bombyx mori silkworm fibroin and reduced graphene oxide.
  • Electrostatic loading of high-molecular-weight nerve growth factor-beta (NGF-β).
  • In vitro assessment of pulsatile drug release triggered by electrical stimuli over 10 days.

Main Results:

  • Successful development of NGF-β-loaded electroresponsive biohybrid composite films.
  • Demonstrated controlled, pulsatile release of NGF-β over a 10-day period.
  • Release was modulated by the on/off application of electrical stimuli.

Conclusions:

  • These electroresponsive biohybrid composites enable precise, on-demand delivery of macromolecular therapeutics.
  • The findings support the development of personalized, biologically responsive scaffolds for neural tissue engineering.
  • Potential translation to other electrically sensitive tissues for enhanced regenerative therapies.