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3D Printing of Tunable Zero-Order Release Printlets.

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  • 1Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.

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Summary

Fused deposition modeling (FDM) 3D printing simplifies manufacturing of personalized medicines. This study demonstrates tunable, zero-order drug release profiles from 3D printed tablets, enabling customized dosing for patients.

Keywords:
3D printed drug productscomputer aided drug design and deliverycontrolled releasedigital pharmaceuticsgastrointestinal modified release drug deliveryhealth and pharmaceutical sciencespersonalized medicinesprinting pharmaceuticalsthree dimensional printing

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Additive Manufacturing

Background:

  • Zero-order release formulations offer consistent drug delivery, improving therapeutic outcomes and patient compliance.
  • Traditional manufacturing of these complex formulations often involves multiple, time-consuming steps.
  • Fused Deposition Modeling (FDM) 3D printing presents a novel approach for on-demand pharmaceutical production.

Purpose of the Study:

  • To explore FDM 3D printing for creating on-demand printlets with zero-order drug release.
  • To evaluate the impact of drug loading and shell design on the properties and release kinetics of 3D printed tablets.
  • To demonstrate the potential for personalized medicine through adjustable dosing in 3D printed formulations.

Main Methods:

  • Hot melt extrusion was used to prepare filaments with varying paracetamol concentrations (10-40% w/w).
  • FDM 3D printing was employed to fabricate printlets with insoluble shells and controlled core infill densities (25-100%).
  • Mechanical properties, physical characteristics, and in vitro drug release profiles were analyzed.

Main Results:

  • 3D printed formulations exhibited tunable zero-order release profiles, with drug release durations ranging from 16 to 48 hours.
  • Drug loading and shell aperture size significantly influenced release kinetics.
  • Varying core infill percentages allowed for precise adjustment of the drug dose within each printlet.

Conclusions:

  • FDM 3D printing offers a simplified, additive manufacturing route for producing extended-release pharmaceutical formulations.
  • Simple modifications in formulation design and printing parameters enable control over drug release kinetics.
  • This technology holds significant promise for the personalized dosing and on-demand manufacturing of medicines.