Novel Imaging Strategies in Systemic Sclerosis.

Area of Science:

• Radiology and Medical Imaging
• Rheumatology
• Pulmonology
• Cardiology

Background:

• Systemic sclerosis (SSc) is a complex autoimmune disease affecting multiple organ systems.
• Early detection of organ and vascular complications is crucial for managing SSc.
• Current imaging modalities are used but novel strategies are needed for improved detection.

Purpose of the Study:

• To review novel imaging strategies for detecting organ and vascular complications in SSc.
• To explore advanced imaging techniques for assessing interstitial lung disease and pulmonary hypertension relevant to SSc.

Main Methods:

• Review of existing and emerging imaging modalities including computed tomography, ultrasound, magnetic resonance imaging, and molecular imaging.
• Focus on techniques applicable to lungs, pulmonary vasculature, heart, skin, vascular tissue, and gastrointestinal tract.
• Consideration of non-ionizing radiation techniques.

Main Results:

• Imaging techniques can identify disease in multiple organs susceptible to SSc.
• Novel strategies show promise for early disease detection, often without ionizing radiation.
• These techniques have potential for use in clinical trials for SSc therapies.

Conclusions:

• Advanced imaging plays a vital role in identifying and monitoring SSc complications.
• Novel imaging approaches offer potential for earlier diagnosis and improved patient outcomes.
• These strategies can accelerate the development and testing of new SSc treatments.