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Updated: Dec 12, 2025

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Remotely Controlled Proton Generation for Neuromodulation.

Jimin Park^1,2,3, Anthony Tabet^2,3,4, Junsang Moon^1,2,3

¹Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge Massachusetts 02139, United States.

|August 14, 2020

Summary

This summary is machine-generated.

Researchers developed magnetic nanoparticles that release protons when exposed to alternating magnetic fields, enabling wireless control of local pH for studying biological processes.

Keywords:

acid-sensing ion channels alternating magnetic fields nanotransducers protons wireless neuromodulation

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Published on: September 2, 2013

Area of Science:

Biomedical Engineering
Nanotechnology
Neuroscience

Background:

Proton-mediated biochemical processes are vital in living organisms.
Current tools lack the ability to precisely control local pH.
Understanding pH regulation is crucial for studying cellular signaling.

Purpose of the Study:

To develop a novel method for wireless control of local pH.
To create nanotransducers that convert alternating magnetic fields into protons.
To investigate the application of pH modulation in neuronal signaling.

Main Methods:

Magnetic nanoparticles (MNPs) were combined with polymeric scaffolds.
AMF exposure induced heat dissipation from MNPs, triggering polymer degradation.
Polyanhydride or polyester hydrolysis released protons into the extracellular space.
pH changes were modulated by polymer chemistry and AMF parameters.

Main Results:

Nanotransducers successfully generated protons in physiological environments.
Remote magnetic control of local pH was achieved wirelessly.
Induced pH changes triggered acid-sensing ion channels in neurons.
Intracellular calcium influx was evoked in neurons via pH modulation.

Conclusions:

The developed nanotransducers offer a wireless method for modulating local pH.
This technology facilitates the investigation of proton roles in biochemical signaling.
The approach has significant potential for neuroscience research and therapeutic applications.