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Fungal Peptic Ulcer Disease in an Immunocompetent Patient
Ridwaan Albeiruti1, Fahad Chaudhary1, Hiren Vallabh2
1Department of Medicine, West Virginia University, Morgantown, WV, USA.
Abstract:
The lifetime prevalence of peptic ulcer disease (PUD) is 5-10%. While PUD in immunocompetent patients is most commonly associated with Helicobacter pylori infection or the use of non-steroidal anti-inflammatory drugs (NSAIDs), other common causes of PUD must also be considered in the differential diagnosis. We describe a case of endoscopic and histological resolution of PUD related to Candida infection in a healthy, immunocompetent woman.
Learning Points:
Peptic ulcer disease (PUD) can be secondary to fungal infections, even in immunocompetent patients.A higher index of suspicion needs to be maintained for fungal causes of PUD, particularly if symptoms do not improve.Recognizing fungal causes of PUD may lead to faster diagnosis and treatment.
Insights
Peptic ulcer disease (PUD) can rarely be caused by fungal infections like Candida, even in healthy individuals. Early recognition of fungal causes is key for effective PUD treatment.
Area of Science:
- Gastroenterology
- Mycology
- Internal Medicine
Background:
- Peptic ulcer disease (PUD) affects 5-10% of the population.
- Common causes include Helicobacter pylori and NSAIDs.
- Fungal causes are rare, especially in immunocompetent individuals.
Purpose of the Study:
- To report a case of PUD secondary to Candida infection in an immunocompetent patient.
- To highlight the importance of considering fungal causes in refractory PUD cases.
Main Methods:
- Case report of a healthy woman with PUD.
- Endoscopic and histological examination.
- Treatment and follow-up.
Main Results:
- Resolution of PUD confirmed endoscopically and histologically.
- Successful treatment of Candida infection.
Conclusions:
- Fungal infections can cause PUD in immunocompetent patients.
- Increased suspicion for fungal PUD is warranted if symptoms persist.
- Prompt diagnosis and treatment of fungal PUD improve outcomes.
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