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Pore Transport and Ion-Pair Transport01:17

Pore Transport and Ion-Pair Transport

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Pore transport and ion-pair formation are critical mechanisms for the absorption and distribution of drugs in the body.
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited  but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct...
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Carrier Transport01:21

Carrier Transport

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The generation of electrical current in semiconductors is fundamentally driven by two mechanisms: drift and diffusion. These processes are essential for the functionality and performance of semiconductor-based devices.
Drift Current:
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Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
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The transport of solutes across the cell membrane is essential for metabolic processes, like maintaining cell size and volume, generating the action potential, exchanging nutrients and gases, etc. Membrane transport can be either passive or active. It can be simple diffusion, facilitated, or mediated transport aided by transport proteins such as transporters and channels.
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Related Experiment Video

Updated: Dec 12, 2025

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
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Stochastic Ionic Transport in Single Atomic Zero-Dimensional Pores.

Jothi Priyanka Thiruraman, Paul Masih Das, Marija Drndić

    ACS Nano
    |August 14, 2020
    PubMed
    Summary

    Researchers created single atomic pores in molybdenum disulfide (MoS2) using aberration-corrected scanning transmission electron microscopy (AC-STEM). These 0D pores exhibit ion transport properties similar to biological ion channels, independent of ion concentration and type.

    Keywords:
    angstrom-size poreatomic porenanoporesub-nm poretransition metal dichalcogenidestwo-dimensional materialzero-dimensional pore

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    Area of Science:

    • Materials Science
    • Nanotechnology
    • Condensed Matter Physics

    Background:

    • Two-dimensional (2D) materials like molybdenum disulfide (MoS2) offer unique platforms for nanoscale devices.
    • Understanding atomic-scale pores is crucial for developing advanced filtration and sensing technologies.
    • Previous studies predicted strong dependence of transport properties on pore size and configuration.

    Purpose of the Study:

    • To fabricate and characterize single atomic zero-dimensional (0D) pores in monolayer MoS2.
    • To investigate the transport properties of these atomic pores.
    • To explore their potential as solid-state analogues of biological ion channels.

    Main Methods:

    • Fabrication of 0D pores using aberration-corrected scanning transmission electron microscopy (AC-STEM).
    • Atomic-scale characterization of pore structure and configurations (zigzag, armchair, mixed).
    • Measurement of electrical conductance and current-voltage (I-V) characteristics.

    Main Results:

    • Successfully created 0D pores with 1-5 missing Mo atoms (0.5-1.2 nm size) in monolayer MoS2.
    • Observed average conductance in the range of 0.6-1 nS, comparable to biological pores.
    • Transport properties showed independence from bulk molarity (10 mM to 3 M KCl) and cation type (K+, Li+, Mg2+).

    Conclusions:

    • Experimental foundation laid for understanding confinement effects in atomic-scale 2D material pores.
    • Demonstrated the potential of 0D MoS2 pores as solid-state analogues of biological ion channels.
    • Opens avenues for novel applications in sensing, filtration, and biomimetic devices.