Related Experiment Video
Updated: Dec 12, 2025

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
Published on: August 1, 2018
Non-natural 3-Arylmorpholino-β-amino Acid as a PPII Helix Inducer
Francesco Vaghi1, Raffaella Bucci1, Francesca Clerici1
1DISFARM-Sez. Chimica Generale e Organica "A. Marchesini", Università degli Studi di Milano, via Venezian 21, 20133 Milano, Italy.
Abstract:
A new non-natural β-amino acid, named 3-Ar-β-Morph, was designed and synthesized via a regio- and diastereoselective Pd-catalyzed C(sp3)H-arylation of the corresponding 2S,6S-(6-methoxymorpholin-2-yl)carboxylic acid, readily available from glucose. According to the computational prevision and confirmed by IR and NMR data, the insertion of 3-Ar-β-Morph in a model foldamer represents a way to stabilize a PPII-like helix through the presence of two γ-turns, secondary structure motifs induced by the morpholine ring, and the trans-tertiary amide bond.
More Related Videos
08:15Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
Published on: June 26, 2020
10:31Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability
Published on: February 3, 2022
Related Concept Videos
Protein Organization
Protein Organization
The primary structure of a protein is its amino acid sequence....
Protein Folding
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
Protein Folding
Basicity of Heterocyclic Aromatic Amines
Amino acids