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Human bocavirus and metapneumovirus in acute wheezing in children-Is there a link with atopy?

Paulina Sobkowiak1, Marcin Mikoś1, Anna Bręborowicz1

  • 1Department of Pneumonology, Allergology and Clinical Immunology, Poznań University of Medical Sciences, Poznan, Poland.

The Clinical Respiratory Journal
|August 14, 2020
PubMed

Insights

A high prevalence of respiratory viruses, including human bocavirus (hBOV) and human metapneumovirus (hMPV), was detected in hospitalized children with acute wheezing. These viruses may be linked to atopy markers in children, suggesting a need for further research.

Area of Science:

  • Pediatric Infectious Diseases
  • Respiratory Virology
  • Clinical Immunology

Background:

  • Viral respiratory tract infections are a primary cause of acute wheezing in children, increasing risks of hospitalization, recurrence, and asthma.
  • While Human Respiratory Syncytial Virus (RSV) and Human Rhinovirus (RV) are well-studied, advances in PCR diagnostics allow for the identification of other pathogens like Human Bocavirus (hBOV) and Human Metapneumovirus (hMPV).

Purpose of the Study:

  • To determine the prevalence of various respiratory viruses in children hospitalized for acute wheezing.
  • To analyze demographic and clinical data associated with these viral infections.

Main Methods:

  • A cohort of 101 children hospitalized for acute wheezing (wheezy bronchitis, acute bronchiolitis, asthma exacerbation) was enrolled.
  • Multiplex real-time PCR assays were employed for the detection of multiple respiratory viruses simultaneously.

Main Results:

  • Over 83% of children had one or more viruses detected, with RSV (44.6%) and RV (23.8%) being most common, followed by hBOV and hMPV (11.9% each).
  • Viral coinfections were present in 37.6% of cases.
  • Significantly higher total IgE levels were observed in hMPV-positive cases compared to RSV and RV.
  • Both hMPV and hBOV showed a significant association with atopic dermatitis.

Conclusions:

  • The study confirms a high viral detection rate (83.2%) in pediatric wheezing illnesses in Poland, with hBOV and hMPV being significant contributors.
  • Findings suggest a potential link between hBOV and hMPV infections and atopy markers, warranting further investigation into their role in childhood respiratory conditions.
Abstract

Keywords:
asthmabocavirusbronchiolitischildrenmetapneumoviruswheezing

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