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Related Concept Videos

Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

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Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
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Drug Delivery: Overview01:16

Drug Delivery: Overview

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

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Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
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Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
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Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
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Drug Distribution: Tissue Binding01:21

Drug Distribution: Tissue Binding

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Upon entering the systemic circulation, drugs can distribute into the interstitial and intracellular fluid of various tissue cells. This distribution is facilitated by the binding of drugs to different cellular components within tissues, which may lead to drug accumulation in specific areas. Drugs bound to tissue components serve as reservoirs that release free drugs back into the system, prolonging the drug's overall action. However, this accumulation can also result in local toxicity.
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Related Experiment Video

Updated: Dec 12, 2025

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform
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Lipoprotein-based drug delivery.

Sara Busatto1, Sierra A Walker1, Whisper Grayson2

  • 1Department of Biochemistry and Molecular Biology, Department of Physiology and Biomedical Engineering, Department of Transplantation, Mayo Clinic, Jacksonville, FL 32224, USA.

Advanced Drug Delivery Reviews
|August 14, 2020
PubMed
Summary
This summary is machine-generated.

Lipoproteins (LPs), nanoparticles from the liver and intestines, are explored as drug delivery vehicles. Their stability and biocompatibility show promise for treating diseases like cancer and atherosclerosis.

Keywords:
Biocompatible nanoparticlesChemotherapyChylomicronsDrug deliveryHigh-density lipoproteinsLow-density lipoproteinsLymphatic transportPurificationSynthetic lipoproteinsVery low-density lipoproteins

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Area of Science:

  • Biochemistry and Nanotechnology

Background:

  • Lipoproteins (LPs) are complex nanoparticles originating from the liver and intestines.
  • They are crucial for transporting lipids throughout the body via receptors and lipoprotein lipase.
  • LPs possess inherent stability, biocompatibility, and targeted delivery capabilities.

Purpose of the Study:

  • To review the techniques for isolating, manufacturing, and loading drugs into LPs.
  • To highlight recent advancements in LP-based drug delivery for various diseases.
  • To explore the diagnostic and therapeutic potential of LPs.

Main Methods:

  • Review of isolation and manufacturing processes for LPs.
  • Analysis of drug-loading strategies for LP formulations.
  • Compilation of recent studies on LP applications in disease treatment and diagnosis.

Main Results:

  • LPs offer a stable and biocompatible platform for drug delivery.
  • Various techniques exist for LP isolation, production, and drug incorporation.
  • LPs are being investigated for treating cancer, atherosclerosis, and other critical conditions.

Conclusions:

  • Lipoprotein-based drug delivery systems show significant therapeutic potential.
  • Further research into LP manufacturing and drug loading can optimize their clinical use.
  • LPs represent a promising nanocarrier for targeted disease treatment and diagnosis.