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[COVID-19 and the impact of cardiovascular comorbidities]

Hatim Seoudy1, Norbert Frey1

  • 1Universitätsklinikum Schleswig-Holstein, Campus Kiel, Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin.

Deutsche Medizinische Wochenschrift (1946)
|August 14, 2020
PubMed

Insights

Coronavirus disease 2019 (COVID-19) significantly impacts cardiovascular health, increasing mortality risk. Continued cardiovascular disease (CVD) treatment is crucial during the pandemic to prevent worse outcomes.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • Coronavirus disease 2019 (COVID-19) is a global pandemic with significant cardiovascular implications.
  • Pre-existing cardiovascular disease (CVD) is linked to severe COVID-19 and increased mortality.
  • COVID-19 can lead to acute cardiovascular syndromes, even with initial respiratory symptoms.

Purpose of the Study:

  • To review the cardiovascular impact of COVID-19.
  • To discuss the role of angiotensin-converting enzyme 2 in COVID-19's cardiovascular effects.
  • To provide guidance on managing cardiovascular conditions during the pandemic.

Main Methods:

  • Literature review of studies on COVID-19 and cardiovascular disease.
  • Analysis of the role of the renin-angiotensin-aldosterone system in COVID-19.
  • Discussion of clinical management strategies and ongoing research.

Main Results:

  • Angiotensin-converting enzyme 2 is a key link between COVID-19 and the cardiovascular system.
  • No evidence suggests harm from renin-angiotensin-aldosterone-system inhibitors in COVID-19 patients.
  • Potential cardiotoxicity of investigational drugs is a concern.
  • COVID-19 may cause long-term cardiovascular damage.

Conclusions:

  • Continue renin-angiotensin-aldosterone-system inhibitor therapy for patients with hypertension or heart failure.
  • Ensure timely treatment of acute cardiovascular disease and adherence to guideline-directed therapy.
  • A long-term management strategy is necessary for patients with potential long-term cardiovascular damage from COVID-19.

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