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Author Spotlight: Developing a Bedside Protocol for Kidney and Genitourinary Ultrasonography
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Update on Hereditary Renal Cancer and Imaging Implications
Stephanie M Walker1, Rabindra Gautam2, Baris Turkbey1
1Molecular Imaging Program, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
Radiologic Clinics of North America
|August 15, 2020
Summary
Hereditary renal cancer syndromes, accounting for up to 8% of kidney cancers, require radiologist awareness for early tumor detection and improved patient outcomes. This review highlights key imaging features of known and emerging hereditary kidney cancer syndromes.
Area of Science:
- Oncology
- Radiology
- Genetics
Background:
- Hereditary factors contribute to a significant portion (up to 8%) of renal cancers.
- Several hereditary renal cancer syndromes are well-established.
- Emerging genetic mutations associated with renal cancer are increasingly recognized.
Purpose of the Study:
- To inform radiologists about hereditary renal cancer syndromes.
- To focus on imaging features and associations of these syndromes.
- To aid in early tumor detection and patient management.
Main Methods:
- Review of established hereditary renal cancer syndromes.
- Discussion of emerging genetic mutations and their imaging characteristics.
- Radiologist-centric perspective on diagnostic findings.
Main Results:
- Identification of key imaging findings for known hereditary renal cancer syndromes.
- Characterization of imaging features for less well-defined genetic mutations.
- Emphasis on the importance of radiologist awareness for early diagnosis.
Conclusions:
- Radiologists play a crucial role in identifying hereditary renal cancer syndromes.
- Awareness of specific imaging findings facilitates early detection.
- Improved understanding aids in patient surveillance and family member screening.
Keywords:
Hereditary leiomyomatosis and renal cell cancerHereditary renal cancer syndromeRenal cell carcinomaTuberous sclerosisVon Hippel-Lindau diseaseMore Related Videos
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