Enhanced allograft survival in H-2 compatible cyclosporine-treated mice

Skin allograft survival time has been prolonged in a variety of animal and human studies. Burn injury, histocompatibility matching, and cyclosporine administration each independently have been shown to increase skin allograft survival times. A mouse model was developed to study these relationships. Histocompatibility matching of mouse H-2 I showed a trend toward skin allograft prolongation when comparing nonburned and burned animals. When there was complete histocompatibility of mouse H-2 and H-4 allograft survival time was significantly prolonged. Cyclosporine administration to the optimally matched donor/recipient combination further enhanced allograft survival. This study demonstrated that histocompatibility matching for the entire H-2 locus correlated with prolonged allograft survival. Optimal histocompatibility and cyclosporine administration further enhanced skin allograft survival in burned mice.