Related Experiment Video
Updated: Dec 12, 2025

Comparison of Agreement and Accuracy using Binocular Wavefront Optometer with Autorefractor and Phoropter
Published on: September 16, 2025
Open versus closed view autorefraction in young adults
Manbir Nagra1, Amna Akhtar2, Byki Huntjens2
1Vision and Eye Research Institute, Anglia Ruskin University, Cambridge, UK.
This study found small but significant differences in refractive error measurements between the closed-view Topcon TRK-2P and open-view Grand Seiko WR-5500 autorefractors in young adults. The Topcon TRK-2P shows potential as a starting point for subjective refraction.
Area of Science:
- Ophthalmology
- Optometry
- Vision Science
Background:
- Objective autorefraction is crucial for determining refractive error.
- Existing research often compares autorefractors in children, with less focus on young adults.
- Modern autorefractors offer different viewing modalities (closed-view vs. open-view).
Purpose of the Study:
- To compare the concordance of non-cycloplegic refractive error measurements between a closed-view (Topcon TRK-2P) and an open-view (Grand Seiko WR-5500) autorefractor.
- To evaluate the agreement between two specific modern objective autorefractors in young adults.
- To assess refractive error using both isolated spherical components and vector notation (MSE, J0, J45).
Main Methods:
- Fifty young adults (aged 20-29 years) participated in the study.
- Non-cycloplegic autorefraction was performed on both eyes using the Topcon TRK-2P and Grand Seiko WR-5500.
- Refractive data were analyzed for the spherical component, Mean Spherical Error (MSE), J0, and J45.
Main Results:
- Mean Spherical Error (MSE) was -1.00 ± 2.40D for the Grand Seiko and -1.23 ± 2.29D for the Topcon.
- Seventy-six percent of measurements from the Topcon TRK-2P were within ±0.50D of the Grand Seiko WR-5500.
- Statistically significant mean differences were found for MSE and J0 (p < 0.01), but not for J45 (p > 0.05).
Conclusions:
- While differences in non-cycloplegic MSE between the two autorefractors are small, they are statistically significant.
- The Topcon TRK-2P may be clinically useful as an initial tool for subjective refraction.
- Further research is needed to minimize measurement discrepancies between different autorefractor models.
Related Concept Videos
Focusing of Light in the Eye
Revisionist Views of Adolescent and Adult Cognition
Angle Closure Glaucoma: Treatment
Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...

