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Calcium channel blockers in systemic hypertension.
W H Frishman1, J A Stroh, S Greenberg
1Albert Einstein College of Medicine, Bronx, New York.
The Medical Clinics of North America
|March 1, 1988
Summary
Calcium channel blockers are effective and safe treatments for systemic hypertension. These drugs are beneficial for long-term management across diverse patient groups, including those with hypertensive urgencies or co-existing conditions like angina.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Systemic hypertension pathophysiology may involve alterations in transmembrane calcium ion flux.
- Calcium channel blockers (CCBs) are recognized as effective antihypertensive agents.
Purpose of the Study:
- To review the efficacy and safety of calcium channel blockers in managing systemic hypertension.
- To highlight the applicability of CCBs in specific patient populations.
Main Methods:
- Literature review of studies on calcium channel blockers and hypertension.
- Analysis of clinical trial data regarding CCB efficacy and safety profiles.
Main Results:
- Calcium channel blockers demonstrate significant efficacy in the long-term treatment of systemic hypertension.
- These drugs possess excellent safety profiles across various patient subgroups.
- CCBs are particularly useful for hypertensive urgencies and patients with conditions like angina pectoris and arrhythmias.
Conclusions:
- Calcium channel blockers are a cornerstone therapy for systemic hypertension due to their proven efficacy and safety.
- Their broad applicability makes them suitable for a wide range of hypertensive patients, including those with complex medical histories.