Related Experiment Video
Updated: Dec 12, 2025

Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures
Published on: November 22, 2024
Corneal ulceration associated with dupilumab use in a patient with atopic dermatitis
Gavin Li1, Meghan Berkenstock1, Uri Soiberman1
1The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 600 North Wolfe St, Baltimore, MD, 21237, USA.
Purpose:
To describe a case of corneal ulceration associated with dupilumab use for atopic dermatitis.
Observations:
A patient developed an inflammatory corneal ulcer 3 weeks after starting bi-weekly intravenous dupilumab therapy. Symptoms resolved with topical prednisolone and discontinuation of the systemic therapy with dupilumab.
Conclusion And Importance:
Dupilumab is known to cause ocular surface inflammation, but we report a novel association between dupilumab use and potentially sight-threatening corneal ulceration.
More Related Videos
Related Concept Videos
Peptic Ulcer Disease I: Introduction
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...

