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Related Experiment Video

Updated: Dec 12, 2025

An Immunocompetent Murine Model for Laser Interstitial Thermal Therapy of Glioblastoma

An Immunocompetent Murine Model for Laser Interstitial Thermal Therapy of Glioblastoma

Published on: November 15, 2024

Laser interstitial thermal therapy.

Katherine G Holste¹, Daniel A Orringer¹

¹Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan.

Neuro-Oncology Advances

|August 15, 2020

Summary

This summary is machine-generated.

Laser interstitial thermal therapy (LITT) offers a minimally invasive option for brain lesions. Studies show LITT is safe and effective, with extent of ablation predicting survival for brain tumors and metastases.

Keywords:

LITT brain metastasis brain tumor

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Area of Science:

Neurosurgery
Oncology
Radiology

Background:

Laser interstitial thermal therapy (LITT) is a minimally invasive surgical technique for brain lesions.
It is an alternative to open craniotomy, suitable for deep-seated or difficult-to-access tumors and patients with high surgical risk.

Purpose of the Study:

To review the current literature on LITT for brain lesions.
To summarize radiological, pathological, and long-term outcomes, including complications.

Main Methods:

A comprehensive literature search of PubMed was conducted for studies on LITT for brain lesions.
Included studies were reviewed for outcomes and complications across various brain tumor types.

Main Results:

For primary brain tumors, a larger extent of ablation and LITT as frontline treatment correlate with improved survival.
In brain metastases, greater ablation extent is linked to survival benefits, with tumor size being a potential factor.
Common complications include weakness, cerebral edema, hemorrhage, seizures, and hyponatremia.

Conclusions:

Despite limitations of small sample sizes and retrospective designs, LITT demonstrates safety and efficacy in selected patients.
LITT is a viable treatment option for specific brain lesion indications.