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Updated: Dec 12, 2025

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

Engineering long-circulating nanomaterial delivery systems.

Zhiyuan Fan¹, Pu Zhu¹, Yucheng Zhu¹

¹Department of Materials Science and Engineering, Drexel University, Philadelphia, PA 19104, USA.

Current Opinion in Biotechnology

|August 16, 2020

Summary

This summary is machine-generated.

Quick clearance of bionanomaterials in circulation is a challenge. Strategies like polymer grafting and biomimetic coatings, such as cell membrane coating, can extend nanomaterial blood circulation time.

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Area of Science:

Bionanomaterials science
Biomedical engineering
Drug delivery systems

Background:

Bionanomaterials face rapid clearance from the bloodstream, limiting their therapeutic potential.
Understanding interactions between nanomaterials and the immune system (complement system) is crucial.
Hepatic, splenic, and renal clearance pathways significantly impact nanomaterial biodistribution.

Purpose of the Study:

To review current strategies for prolonging nanomaterial blood circulation time.
To analyze the mechanisms of nanomaterial clearance by biological systems.
To discuss advanced techniques for enhancing nanomaterial longevity in vivo.

Main Methods:

Review of literature on nanomaterial-biological interactions.
Analysis of clearance pathways in major organs (liver, spleen, kidneys).
Discussion of surface modification techniques: polymer grafting and biomimetic coatings.

Main Results:

Grafting polymers onto nanomaterials can reduce opsonization and immune recognition.
Biomimetic approaches, including cell membrane coating and hybrid vesicles, offer effective camouflage.
These strategies demonstrate potential in extending circulation times by evading rapid clearance.

Conclusions:

Surface modification is key to overcoming rapid clearance of bionanomaterials.
Polymer grafting and biomimetic coatings represent promising avenues for improving nanomaterial circulation.
Further research is needed to optimize these strategies for clinical applications.