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Quantification of Circulating Pig-Specific DNA in the Blood of a Xenotransplantation Model
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Progress towards xenogenic tolerance.

Erin M Duggan1,2, Adam Griesemer1,2

  • 1Columbia Center for Translational Immunology, Columbia University College of Physicians and Surgeons.

Current Opinion in Organ Transplantation
|August 16, 2020
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Summary
This summary is machine-generated.

Recent advances in xenotransplantation tolerance include mixed chimerism and thymic transplantation. Novel strategies like hybrid thymus and regulatory T cells show promise for long-term graft acceptance without immunosuppression.

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Area of Science:

  • Immunology
  • Transplantation Biology
  • Regenerative Medicine

Background:

  • Xenotransplantation offers a potential solution to organ shortages.
  • Achieving long-term graft tolerance remains a significant challenge.

Purpose of the Study:

  • To review recent progress in inducing tolerance for xenotransplantation.
  • To highlight novel strategies for promoting immune acceptance of foreign organs.

Main Methods:

  • Mixed chimerism induction via intra-bone bone marrow transplantation.
  • Development of hybrid thymus for T-cell selection.
  • Utilizing regulatory T cells (Tregs) and monoclonal antibodies (e.g., anti-CD2).

Main Results:

  • Intra-bone bone marrow transplantation promotes durable chimerism and improves graft function.
  • Hybrid thymus facilitates donor/recipient T-cell selection, fostering tolerance.
  • Tregs and anti-CD2 antibodies show potential in suppressing immune responses while preserving regulatory cells.

Conclusions:

  • Significant advancements have been made in xenotransplantation tolerance.
  • A combination of strategies is likely necessary for sustained tolerance without immunosuppression.