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Related Concept Videos

Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

645
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
645

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A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection
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Microtechnologies for inner ear drug delivery.

Farzad Forouzandeh1, David A Borkholder

  • 1Microsystems Engineering, Rochester Institute of Technology, Rochester, New York, USA.

Current Opinion in Otolaryngology & Head and Neck Surgery
|August 16, 2020
PubMed
Summary
This summary is machine-generated.

Microtechnologies enhance inner ear drug delivery for auditory dysfunction treatment. Innovations in micropumps, coatings, and microneedles offer controlled access for protection and regeneration therapies.

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Area of Science:

  • Otolaryngology
  • Biomedical Engineering
  • Drug Delivery Systems

Background:

  • Inner ear drug delivery is crucial for treating auditory dysfunction.
  • Microtechnologies are vital for precise cochlear access and controlling drug release.
  • Current research focuses on innovative methods for inner ear therapeutic interventions.

Purpose of the Study:

  • To review recent advancements in microtechnology for inner ear drug delivery.
  • To examine the role of these technologies in both clinical and animal research.
  • To highlight their application in cochlear access and pharmacokinetic control.

Main Methods:

  • Development of micropump technologies for dynamic flow rate control and timed delivery of multiple agents.
  • Integration of micropumps with cochlear implants or independent use with cochleostomy/round window membrane delivery.
  • Application of advanced coatings on cochlear implants for sustained drug release and cell-based therapies.
  • Utilization of microneedles for controlled microperforation of the round window membrane.

Main Results:

  • Micropumps enable timed delivery for protection and regeneration therapies.
  • Cochlear implant coatings show sustained steroid release and reduced electrode impedances in humans.
  • Cell-coated implants enhance spiral ganglion neuron survival in animal models and are safe in humans.
  • Microneedles improve round window membrane permeability for optimized drug release.

Conclusions:

  • Microsystem technologies offer improved and controlled inner ear access for drug delivery.
  • These technologies can be used independently or with cochlear implants.
  • Advancements support novel therapeutic strategies for auditory dysfunctions.