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[Oncogenic virus induction by halogenated pyrimidines (author's transl)]
Archiv Fur Geschwulstforschung
|January 1, 1977
Summary
Halogenated pyrimidines like iododeoxyuridine (IdU) and bromodeoxyuridine (BdU) can activate oncogenic viruses integrated into vertebrate cells. This review explores their effects on cell differentiation and virus induction mechanisms.
Area of Science:
- Virology
- Molecular Biology
- Cell Biology
Context:
- Oncogenic viruses, including DNA and RNA types, integrate into vertebrate cell genomes.
- Physical, chemical, and biological agents can induce the expression of these integrated viruses.
- Halogenated pyrimidines, specifically iododeoxyuridine (IdU) and bromodeoxyuridine (BdU), are known inducers.
Purpose:
- To review the action of IdU and BdU on cell differentiation systems.
- To describe the activation of oncogenic viruses, particularly C-RNA viruses, by these agents.
- To discuss potential mechanisms underlying virus induction.
Summary:
- Idododeoxyuridine (IdU) and bromodeoxyuridine (BdU) are halogenated pyrimidines that induce oncogenic viruses integrated into vertebrate cell genomes.
- Their effects on specific cell differentiation processes like chondrogenesis and myogenesis are examined.
- The review details the activation of C-RNA viruses and explores proposed mechanisms of induction.
Impact:
- Provides insights into the mechanisms of viral activation by chemical agents.
- Highlights the role of halogenated pyrimidines in modulating oncogenic virus expression.
- Informs research on virus-host interactions and potential therapeutic strategies targeting viral induction.