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Related Concept Videos

Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen01:16

Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen

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Oxygen therapy is a pivotal aspect of medical care, particularly for patients with respiratory ailments. Two prominent oxygen-delivering systems include the Venturi mask and the transtracheal oxygen catheter.
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
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Oxygen Delivering System I: Nasal Cannula and Face Mask01:26

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The human body requires oxygen to function, and when the natural process of respiration is hindered, external devices, including the following, are needed to help deliver this vital gas.
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Suggested flow rate: The suggested flow rate for a nasal cannula typically ranges between 1 and 6 L/min.
Oxygen percentage setting:...
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Related Experiment Video

Updated: Dec 11, 2025

Fabrication and Operation of an Oxygen Insert for Adherent Cellular Cultures
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Hyperbaric polymer microcapsules for tunable oxygen delivery.

Tien Nguyen1, Yifeng Peng2, Raymond P Seekell2

  • 1Department of Cardiology, Boston Children's Hospital, Boston, MA 02115, USA.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|August 18, 2020
PubMed
Summary
This summary is machine-generated.

Engineered polymeric microcapsules (PMCs) offer tunable oxygen delivery for treating hypoxia. This breakthrough allows independent control over oxygen flux and duration, crucial for diverse medical applications.

Keywords:
DeliveryHyperbaricHypoxiaMicrocapsuleOxygenPolymersPressurization

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Area of Science:

  • Biomaterials Engineering
  • Biomedical Engineering
  • Materials Science

Background:

  • Hypoxia, resulting from trauma, transplantation, or tumors, necessitates oxygen delivery systems.
  • Existing oxygen-generating biomaterials lack tunable control over oxygen flux and delivery duration.
  • Precise control over oxygen delivery is vital for treating various etiologies of tissue hypoxia.

Purpose of the Study:

  • To engineer a novel system for tunable oxygen delivery.
  • To demonstrate independent control over oxygen flux and delivery duration.
  • To address limitations of current oxygen-generating biomaterials.

Main Methods:

  • Utilized hyperbarically-loaded polymeric microcapsules (PMCs) with hollow cores and polymeric shells.
  • Investigated oxygen delivery dependence on PMC shell permeability, thickness, and pressure gradients.
  • Incorporated an intermediate oil layer to manage pressure gradients and prevent rapid outgassing.

Main Results:

  • Demonstrated that oxygen delivery from PMCs is controllable via shell properties and pressure.
  • Showcased the ability to independently manipulate oxygen flux and duration.
  • Validated the efficacy of an intermediate oil layer in stabilizing oxygen release post-depressurization.

Conclusions:

  • Polymeric microcapsules (PMCs) provide a tunable platform for controlled oxygen delivery.
  • This technology offers independent manipulation of oxygen flux and duration, overcoming limitations of previous methods.
  • The developed PMCs hold significant potential for therapeutic applications requiring precise oxygen management.