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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes
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Maternal Characteristics Associated With Preconception Marijuana Use.

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Approximately 8% of women reported marijuana use before pregnancy. Factors like marital status, education, and state legalization were associated with use, which was also linked to depression and other substance use.

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Area of Science:

  • Reproductive Health
  • Public Health
  • Substance Use Research

Background:

  • Marijuana use is increasing among U.S. women.
  • Unintended pregnancies are more common among marijuana users.
  • Potential risks of maternal marijuana use necessitate understanding preconception use factors.

Purpose of the Study:

  • Estimate preconception marijuana use prevalence in U.S. women.
  • Identify maternal characteristics associated with preconception marijuana use.
  • Inform public health strategies for reproductive-aged women.

Main Methods:

  • Analysis of 2016 Pregnancy Risk Assessment Monitoring System (PRAMS) data from six U.S. states.
  • Comparison of characteristics between marijuana-using and non-using respondents.
  • Chi-square tests and logistic regression models used for statistical analysis.

Main Results:

  • Nearly 8% of women reported marijuana use in the month preceding pregnancy.
  • Marital status, education, parity, and state marijuana laws were associated with use.
  • Marijuana users were 3-5 times more likely to report depression, tobacco, and alcohol use.

Conclusions:

  • Reproductive-aged women should be screened for marijuana use, particularly those planning pregnancy or at risk of unintended pregnancy.
  • Encourage cessation of marijuana use due to associations with depression and other substance use.
  • Public health interventions should address preconception marijuana use and co-occurring substance use.