Related Experiment Video
Updated: Dec 11, 2025
Isolation and Direct Neuronal Reprogramming of Mouse Astrocytes
Published on: July 7, 2022
Location, Location, Location: Transcriptional Control of Astrocyte Heterogeneity
Marci F Rosenberg1, Anna V Molofsky1
1Department of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, 94158, USA; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, 94158, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, 94158, USA.
Abstract:
Huang et al. have found that deletion of astrocyte lineage-specifying transcription factor NFIA from mature astrocytes alters astrocyte morphology, molecular identity, and synaptic-support capacity in a region-specific manner. We discuss the implications of these findings in light of emerging roles for astrocytes in immune cell crosstalk.
