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Plasma ceramides are associated with coronary atherosclerotic burden in patients with ST-segment elevation myocardial

Weili Pan1, Longyan Li2, Meng Sun1

  • 1Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Province Heilongjiang, China; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, Province Heilongjiang, China.

International Journal of Cardiology
|August 18, 2020
PubMed

Insights

Elevated plasma ceramides (Cer) are linked to higher atherosclerotic burden in ST-segment elevation myocardial infarction (STEMI) patients. These findings suggest ceramides play a proatherogenic role in cardiovascular disease.

Area of Science:

  • Cardiovascular Research
  • Lipidomics
  • Biochemistry

Background:

  • Plasma ceramides (Cer) are bioactive lipids implicated in the pathogenesis of atherosclerotic coronary artery disease (CAD).
  • Ceramides are associated with major adverse cardiovascular events (MACEs).

Purpose of the Study:

  • To investigate the association between plasma ceramide levels and the extent of atherosclerotic burden.
  • To evaluate atherosclerotic burden using the Synergy Between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score.

Main Methods:

  • Retrospective analysis of 248 ST-segment elevation myocardial infarction (STEMI) patients.
  • Plasma ceramide concentrations were measured using Rapid Resolution Liquid Chromatography coupled with Quadrupole Time-of-Flight Mass Spectrometry (RRLC-Q-TOF/MS).
  • SYNTAX scores were automatically calculated.

Main Results:

  • STEMI patients exhibited higher plasma ceramide levels compared to normal donors (p < .001).
  • Positive correlations were observed between SYNTAX score and specific ceramides: Cer(d18:1/16:0), Cer(d18:1/18:0), Cer(d18:1/24:1), and Cer(d18:1/24:0).
  • Higher levels of Cer(d18:1/16:0), Cer(d18:1/18:0), and Cer(d18:1/24:1) were independently associated with higher SYNTAX scores after adjusting for traditional risk factors.

Conclusions:

  • Elevated plasma levels of Cer(d18:1/16:0), Cer(d18:1/18:0), and Cer(d18:1/24:1) are independent predictors of high atherosclerotic burden in STEMI patients.
  • These findings support a proatherogenic role for ceramides in cardiovascular disease.
Abstract

Keywords:
Plasma ceramidesRRLC-Q-TOF/MSSTEMISYNTAX score

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